In 1981, Richard W. Darrell, MD, reviewed literature relating to TSPK and its association with a histocompatibility antigen HLA DR3.  Both HLA D and HLA DR antigens are associated with the immune response genes, and HLD DR3 antigen may interfere with the immune response of patients of Thygeson’s Superficial Punctate Keratitis to endogenous and exogenous […]