Thygesons Superficial Punctate Keratopathy

Thygeson’s Superficial Punctate Keratitis Imaging Studies

Phillips Thygeson is who Thygeson’s Superficial Punctate Keratitis (TSPK) is named after when he identified and first published details in the American Medical Journal over 60 years ago in a 1950 issue. Treating the symptoms of TSPK is carried out in many ways and the methods chosen may depend on the attending physician and the severity of the case for each individual. There has been some Thygeson’s Superficial Punctate Keratitis imaging studies conducted.

One such study was performed to evaluate and describe changes that could be detected with a confocal microscope. In the study, a confocal microscope was used on six TSPK patients. TSPK patients had both eyes examined and so were the eyes of 2 patients with unilateral TSPK. Certain controls were in place during the experiment in the laboratory.  The results of the experiment revealed out of norm nerve fibers, clouded by haze, were noted in the subepithelial nerve above the membrane in TSPK.

There was a substantial amount of haze in three different areas that are high reflectivity, reflective bodies, and microdots. It was reported that keratocytes showed very reflective nuclei and showed that the cell bodies were not uniform. The size, shape, and orientation of the cell bodies were described as irregular by the recording staff.  It seems that the documented changes correlated to the duration of the TSPK, were found in areas that had no lesions, and were not recorded in the participants with normal eyes.

The conclusions showed many abnormalities relating to the subepithelial nerve plexus, the Bowman membrane, and the anterior stroma that relates to the length of the disease. These led to other observations and indications that these three factors play a part in cornea diseases and may show up after surgery on a cornea.  All of these interactions have led to speculation that they play a role in TSPK.  Thygeson’s Superficial Punctate Keratitis imaging studies continue in many parts of the world today.

The disease is known as Thygeson’s Superficial Punctate Keratitis, Thygeson’s Superficial Punctate Keratopathy or TSPK.

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