Author Archive
Welcome to thygesons.com
Thygeson’s SPK is also known as TSPK, Thygesons or Thygeson’s Superficial Punctate Keratopathy, Thygeson’s Superficial Punctate Keratitis, Thygeson’s Disease, or Thygeson’s Syndrome. It is a human eye ailment that may affect one or both eyes. Share the link http://www.thygesons.com.
Ikervis Ciclosporin available in Scotland, UK.
The Scottish Medicines Consortium has completed its assessment of the use of ciclosporin 1mg/mL (0.1%) and advises NHS boards and Area Drug and Therapeutic Committees on its use in Scotland. (SMC No (1089/15). Ikervis Ciclosporin is used in the treatment of severe keratitis in adult patients with dry eye disease, which has not improved despite […]
Thygesons Superficial Punctate Keratitis (TSPK) Treatment and Management
Various treatments have been used to try and treat Thygeson’s SPK; however, many have been unsuccessful. Antibiotics are not successful and are ineffective in treating the condition. In some instances antivirals have been used and have had mixed results resulting in mild improvements with the use of trifluridine. Contrary information also suggests that the use […]
HLD DR3 antigen affects response to Thygeson’s Superficial Punctate Keratitis
In 1981, Richard W. Darrell, MD, reviewed literature relating to TSPK and its association with a histocompatibility antigen HLA DR3. Both HLA D and HLA DR antigens are associated with the immune response genes, and HLD DR3 antigen may interfere with the immune response of patients of Thygeson’s Superficial Punctate Keratitis to endogenous and exogenous […]
Patient Diagnosis and Management of Thygeson’s Superficial Punctate Keratitis
Thygeson’s Superficial Punctate Keratitis (TSPK) is a chronic eye disease that has remissions and exacerbations for a few years to decades. Patients typically present with whitish-grey, intraepithelial corneal lesions with no or limited conjunctival involvement. While the etiology of the disease remains controversial, it does have a genetic association with HLA-DR3, which is an antigen […]
Cyclosporine Ophthalmic Emulsion 0.05% – Restatis by Allergan
Produced as a sterile, preservative-free emulsion made from a white powder, Cyclosporine acts as a topical immunomodulator that has an anti-inflammatory effect. While Cyclosporine is the active ingredient, there are a number of inactive ingredients including polysorbate 80, glycerin, carbomer copolymer type A, castor oil, purified water, and sodium hydroxide to adjust its pH level. […]
No Cyclosporine Eye Drops in the UK
There are benefits associated with the treatment of Thygeson’s SPK using Cyclosporine. However, it needs to be used at a low concentration level. The treatment appears beneficial, yet it is not marketed at low concentrations in the UK under the National Health Service. Discussions with a local consultant in Edinburgh suggests that while the long-term […]
Topical Therapy in Thygeson’s Superficial Punctate Keratitis
When someone is affected by the severity of Thygeson’s Superficial Punctate Keratitis or in any of its signs, symptoms, or following remission, various therapies are considered depending on the severity of the disease at the time the patient presents to the eye care specialist. Where a patient presents with a mild case, then they may […]
The Morphology of Thygeson’s Superficial Punctate Keratitis Lesions
Thygeson’s Superficial Punctate Keratitis affects cells that lie within the intraepithelial region of the cornea. At an individual level, each entity is small, round, light reflecting cells around 10-15 μm in diameter). The disease can present itself as a single cell entity or cells clustered in small groups or they can aggregate into lesions that […]
Corticosteroids and Cyclosporine Treatments for Thygeson’s SPK
Studying the opacities or lesions created by Thygeson’s SPK, also known as Thygeson’s Superficial Punctate Keratopathy, Thygeson’s Superficial Punctate Keratitis and TSPK, shows a crystalline appearance on the corneal surface that resemble snowflakes. They vary in location and fluctuate in numbers even on a weekly basis during a flare up of the condition affecting the […]